USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P63261 USC-OGP 2-DE database:  P63261 P63261 General information about the entry View entry in simple text format Entry name ACTG_HUMAN Primary accession number P63261 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Actin, cytoplasmic 2; AltName: Full=Gamma-actin; Contains: RecName: Full=Actin, cytoplasmic 2, N-terminally processed;. Gene name Name=ACTG1 Synonyms=ACTG Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current Comments SECONDARY ACCESSION NUMBER: P02571 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0066: pI=4.63; Mw=52202 SPOT OGP-0074: pI=4.45; Mw=50169 SPOT OGP-0083: pI=4.72; Mw=45607 SPOT OGP-0100: pI=5.04; Mw=40309 SPOT OGP-0111: pI=4.86; Mw=38026 SPOT OGP-0129: pI=4.73; Mw=34534 SPOT OGP-0135: pI=4.91; Mw=33585 SPOT OGP-0144: pI=5.03; Mw=31988 SPOT OGP-0145: pI=4.87; Mw=31876 SPOT OGP-0152: pI=5.02; Mw=30562 SPOT OGP-0158: pI=4.92; Mw=30031 SPOT OGP-0249: pI=4.92; Mw=16575 SPOT OGP-0252: pI=4.96; Mw=16353 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0274: pI=5.21; Mw=120018 SPOT OGP-0286: pI=5.13; Mw=107696 SPOT OGP-0292: pI=5.12; Mw=95000 SPOT OGP-0297: pI=5.12; Mw=84870 SPOT OGP-0374: pI=5.18; Mw=48891 SPOT OGP-0377: pI=5.10; Mw=48653 SPOT OGP-0379: pI=5.14; Mw=48298 SPOT OGP-0400: pI=5.45; Mw=44776 SPOT OGP-0401: pI=5.41; Mw=44667 SPOT OGP-0402: pI=5.34; Mw=44558 SPOT OGP-0403: pI=5.64; Mw=44558 SPOT OGP-0407: pI=5.41; Mw=42956 SPOT OGP-0408: pI=5.53; Mw=42956 SPOT OGP-0412: pI=5.53; Mw=42022 SPOT OGP-0473: pI=5.13; Mw=31502 SPOT OGP-0491: pI=5.13; Mw=29469 SPOT OGP-0503: pI=5.26; Mw=27760 SPOT OGP-0511: pI=5.11; Mw=26520 SPOT OGP-0523: pI=5.28; Mw=25695 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0616: pI=5.13; Mw=102264 SPOT OGP-0618: pI=5.15; Mw=93758 SPOT OGP-0656: pI=5.20; Mw=54807 SPOT OGP-0679: pI=5.11; Mw=50050 SPOT OGP-0681: pI=5.14; Mw=49554 SPOT OGP-0691: pI=5.41; Mw=45994 SPOT OGP-0695: pI=5.32; Mw=44865 SPOT OGP-0696: pI=5.47; Mw=44865 SPOT OGP-0701: pI=5.29; Mw=44531 SPOT OGP-0708: pI=5.56; Mw=42795 SPOT OGP-0711: pI=5.55; Mw=42162 SPOT OGP-0765: pI=5.13; Mw=31522 SPOT OGP-0793: pI=5.23; Mw=29794 SPOT OGP-0797: pI=5.10; Mw=29413 SPOT OGP-0800: pI=5.24; Mw=28514 SPOT OGP-0802: pI=5.25; Mw=28162 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0925: pI=6.02; Mw=45707 SPOT OGP-0927: pI=6.89; Mw=45068 SPOT OGP-0929: pI=8.15; Mw=44333 SPOT OGP-0930: pI=7.22; Mw=44126 SPOT OGP-0934: pI=5.53; Mw=43508 SPOT OGP-0938: pI=5.85; Mw=42599 SPOT OGP-0940: pI=10.08; Mw=42499 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1161: pI=5.44; Mw=49904 SPOT OGP-1172: pI=6.39; Mw=46315 SPOT OGP-1173: pI=5.91; Mw=45157 SPOT OGP-1175: pI=6.62; Mw=45030 SPOT OGP-1176: pI=5.57; Mw=44777 SPOT OGP-1181: pI=5.40; Mw=44276 SPOT OGP-1189: pI=5.12; Mw=42209 SPOT OGP-1201: pI=5.96; Mw=39564 SPOT OGP-1216: pI=6.30; Mw=36464 SPOT OGP-1239: pI=6.05; Mw=32675 SPOT OGP-1246: pI=5.01; Mw=31502 SPOT OGP-1256: pI=5.39; Mw=30456 SPOT OGP-1259: pI=5.08; Mw=30030 SPOT OGP-1260: pI=5.04; Mw=29946 Cross-references UniProtKB/Swiss-Prot P63261; ACTG_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ACTG_HUMAN Primary accession number P63261 Secondary accession number(s) A8K7C2 P02571 P14104 P99022 Q5U032 Q96E67 Sequence was last modified on  July 21, 1986 (version 1) Annotations were last modified on  March 15, 2017 (version 155) Name and origin of the protein Description RecName: Full=Actin, cytoplasmic 2; AltName: Full=Gamma-actin; Contains: RecName: Full=Actin, cytoplasmic 2, N-terminally processed; Gene name Name=ACTG1 Synonyms=ACTG Encoded on Name=ACTG1; Synonyms=ACTG Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Isopeptide bond; Mental retardation; Methylation; Non-syndromic deafness; Nucleotide-binding; Oxidation; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X04098; CAA27723.1; -; mRNA EMBL M19283; AAA51579.1; -; Genomic_DNA EMBL AK291937; BAF84626.1; -; mRNA EMBL BT019856; AAV38659.1; -; mRNA EMBL BC000292; AAH00292.1; -; mRNA EMBL BC001920; AAH01920.1; -; mRNA EMBL BC007442; AAH07442.1; -; mRNA EMBL BC009848; AAH09848.1; -; mRNA EMBL BC010999; AAH10999.1; -; mRNA EMBL BC012050; AAH12050.1; -; mRNA EMBL BC015005; AAH15005.1; -; mRNA EMBL BC015695; AAH15695.1; -; mRNA EMBL BC015779; AAH15779.1; -; mRNA EMBL BC018774; AAH18774.1; -; mRNA EMBL BC053572; AAH53572.1; -; mRNA EMBL M16247; AAA51580.1; -; mRNA CCDS CCDS11782.1; -; . PIR A28098; ATHUG; . PIR JC5818; JC5818; . RefSeq NP_001186883.1; NM_001199954.1; . RefSeq NP_001605.1; NM_001614.3; . UniGene Hs.514581; -; . UniGene Hs.713764; -; . PDB 5JLH; EM; 3.90 A; A/B/C/D/E=2-375 PDBsum 5JLH; -; . ProteinModelPortal P63261; -; . SMR P63261; -; . BioGrid 106586; 140; . IntAct P63261; 74; . MINT MINT-4998686; -; . STRING 9606.ENSP00000331514; -; . iPTMnet P63261; -; . PhosphoSitePlus P63261; -; . SwissPalm P63261; -; . BioMuta ACTG1; -; . DMDM 54036678; -; . DOSAC-COBS-2DPAGE P63261; -; . OGP P63261; -; . REPRODUCTION-2DPAGE P63261; -; . SWISS-2DPAGE P63261; -; . EPD P63261; -; . MaxQB P63261; -; . PaxDb P63261; -; . PeptideAtlas P63261; -; . PRIDE P63261; -; . TopDownProteomics P63261; -; . DNASU 71; -; . Ensembl ENST00000331925; ENSP00000331514; ENSG00000184009; . Ensembl ENST00000573283; ENSP00000458435; ENSG00000184009; . Ensembl ENST00000575087; ENSP00000459124; ENSG00000184009; . Ensembl ENST00000575842; ENSP00000458162; ENSG00000184009; . Ensembl ENST00000576544; ENSP00000461672; ENSG00000184009; . Ensembl ENST00000615544; ENSP00000477968; ENSG00000184009; . GeneID 71; -; . KEGG hsa:71; -; . UCSC uc002kak.3; human; . CTD 71; -; . DisGeNET 71; -; . GeneCards ACTG1; -; . GeneReviews ACTG1; -; . H-InvDB HIX0001479; -; . H-InvDB HIX0199868; -; . HGNC HGNC:144; ACTG1; . HPA HPA041264; -; . HPA HPA041271; -; . MalaCards ACTG1; -; . MIM 102560; gene; . MIM 604717; phenotype; . MIM 614583; phenotype; . neXtProt NX_P63261; -; . OpenTargets ENSG00000184009; -; . Orphanet 90635; Autosomal dominant non-syndromic sensorineural deafness type DFNA; . Orphanet 2995; Baraitser-Winter syndrome; . PharmGKB PA24468; -; . eggNOG KOG0676; Eukaryota; . eggNOG COG5277; LUCA; . GeneTree ENSGT00760000118957; -; . HOVERGEN HBG003771; -; . InParanoid P63261; -; . KO K05692; -; . OMA TFQQART; -; . OrthoDB EOG091G08LD; -; . PhylomeDB P63261; -; . TreeFam TF354237; -; . Reactome R-HSA-1445148; Translocation of GLUT4 to the plasma membrane; . Reactome R-HSA-190873; Gap junction degradation; . Reactome R-HSA-196025; Formation of annular gap junctions; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-3928662; EPHB-mediated forward signaling; . Reactome R-HSA-3928665; EPH-ephrin mediated repulsion of cells; . Reactome R-HSA-418990; Adherens junctions interactions; . Reactome R-HSA-437239; Recycling pathway of L1; . Reactome R-HSA-4420097; VEGFA-VEGFR2 Pathway; . Reactome R-HSA-445095; Interaction between L1 and Ankyrins; . Reactome R-HSA-446353; Cell-extracellular matrix interactions; . Reactome R-HSA-5626467; RHO GTPases activate IQGAPs; . Reactome R-HSA-5663213; RHO GTPases Activate WASPs and WAVEs; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . SignaLink P63261; -; . SIGNOR P63261; -; . ChiTaRS ACTG1; human; . GeneWiki ACTG1; -; . GenomeRNAi 71; -; . PMAP-CutDB P63261; -; . PRO PR:P63261; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000184009; -; . CleanEx HS_ACTB; -; . CleanEx HS_ACTG1; -; . ExpressionAtlas P63261; baseline and differential; . Genevisible P63261; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0097433; C:dense body; ISS:AgBase; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; ISS:AgBase; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; ISS:AgBase; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0005200; F:structural constituent of cytoskeleton; IC:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0034329; P:cell junction assembly; TAS:Reactome; . GO GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0051592; P:response to calcium ion; IEA:Ensembl; . GO GO:0009612; P:response to mechanical stimulus; IEA:Ensembl; . GO GO:0001895; P:retina homeostasis; IEP:UniProtKB; . GO GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; . InterPro IPR004000; Actin; . InterPro IPR020902; Actin/actin-like_CS; . InterPro IPR004001; Actin_CS; . PANTHER PTHR11937; PTHR11937; 1; . Pfam PF00022; Actin; 1; . PRINTS PR00190; ACTIN; . SMART SM00268; ACTIN; 1; . PROSITE PS00406; ACTINS_1; 1; . PROSITE PS00432; ACTINS_2; 1; . PROSITE PS01132; ACTINS_ACT_LIKE; 1; .

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